Many cases involve children or infants whose parents accidentally measure the wrong dose in the middle of the night, or combine different medicines without realizing that they all contain the same ingredient - for example, Tylenol for a fever and then a second medicine for a cough. each year as a result of acetaminophen overdose.
More than 44,000 people end up in the emergency room and four hundred people die in the U.S.
In extreme cases patients die unless they get a liver transplant. But taking more than the maximum recommended dose of four grams per day can damage the liver. in 2009 alone, making it the most widely-used over-the-counter or prescription drug in the country.Īvailable without a prescription for more than 50 years, the drug is safe when used as directed. More than 27 billion doses of acetaminophen-containing products were sold in the U.S. take at least one acetaminophen-containing product a week. Known for relieving minor aches and pains without upsetting the stomach like some other pain medicines, acetaminophen is a major ingredient in Tylenol and more than 600 other store brand pain relievers, fever reducers, cold remedies and allergy medicines, as well as prescription painkillers like Percocet and Vicodin. The results appear online and are scheduled to be published in the July 2015 issue of the Journal of Theoretical Biology. The findings suggest that giving patients glutamine - a common amino acid in the body - alongside the standard antidote for acetaminophen overdose could prevent liver damage and boost the body's ability to recover.
Researchers at Duke University have developed a mathematical model of acetaminophen metabolism based on data from lab rats.
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